Monday, 3 October 2016

EFFECTS OF BIOAEROSOLS ON HUMANS

Several findings of epidemiological research indicate that exposure to high concentration of microorganisms frequently leads to allergies, asthma, hay fever (Bjornsson et al., 1995; Newson et al., 2000), pneumonia (Siersted and Gravesen, 1993), and many other health side-effects, including infections (Renn et al., 2001). In recent years, dramatic increase in the number of allergic reactions to fungal sores has been reported, and young people do constitute a large group of allergic sufferers, whose symptoms persist throughout the year (Jain, 2000). It has also been established that bioaerosols may account for 10-20% of all endemic
nosoeomial infections (Brachman, 1970). Respiratory illness and lung diseases are among the most widely studied bioaerosol-associated diseases, acute toxic effects, allergies and cancer (Douwes et al., 2003, Stetzenbach et al., 2004). While several bacterial such Staphylococcus aureus, Sphigonomas Paucimobilis and Pseudomonus aeroginosa are known to cause the majority of nosocomial infections (Gilbert et al., 2010). Also, various metabolites secreted by microorganisms such as endotoxins, (membrane lipopolysachrides shed by Gram-negative bacteria) and fungal mycotoxins can also trigger respiratory problems (Braun-Fahrlander, et al., 2002; Jie, et al., 2011).
      The closest known association of human disease of microbial origin and dust storms are the outbreak of meningitis (primarily due to Neissenia meningitis infection) that occurs within the “meningitis belt” of the North Africa (Sultan et al., 2005). These outbreak occur frequently in the Sahel region of North Africa between the months of February and May and affects as many as 200,000 individuals annuals (Sultan et al., 2005; Molesworth et al., 2003). Isolates of Neisseria meningitis have also been retrieved from settled-dust samples from Kuwait together with other pathogens such as Staphylocus aureus (wide range of infections) and Ralstonia paucula (e.g, Septicemia, Peritonitis). Bacterial species have also been collected in the air of Bamako, Mali during strong dust events (Kellogg et al., 2004) as well as in the African dust corridor over the mid-Atlantic ridge (Griffin, et al., 2006). In the atmosphere over the USA virgin Islands the opportunistic pathogen Pseudomonas aeroginosa, which can cause fatal infection in burn patients, has been isolated (Rahn, et al., 1977), whereas several pathogens have also been identified in the atmosphere of Erdemli, Turkey (Griffin, et al., 2007) and crete, Greece (Polymenakou, et al., 2008), during dust events. A detailed overview of studies associated with desert dust transportation of microorganisms and their implications for human health has been presented by Griffin et al., (Griffin, et al., 2007).
    In the last decades, there have been increasing numbers of reports of marine diseases and epidemics, affecting a wide range of organisms, such as plants, invertebrates and mammals (Griffin, et al., 2004; Harvell, et al.,1999). Several attempts have been made to connect these diseases with climate change whereas special attention has been given on identifying possible connections among dust, iron, microbes and climate change. Recent studies have assumed that the iron carried with desert-dust, in addition to triggering harmful algal blooms can also trigger growth of opportunistic marine microbial pathogens that may be present in the transported dust or may already exist in the ecosystem (Hayes, et al., 2001).
     The first substantial evidence of a microbial link was provided when the terrestrial fungus Aspergillus sydowii, which is unable to reproduce in seawater but can be carried with dust storms, was identified as the causative agents of sea fan disease (Smith et al., 1996). Furthermore, a strong connection between African desert dust and Caribbean coral reef decline was also demonstrated when Shinn et al., 2000) noticed that a relation between two decaded of corel reef decline and the coincident increase in African dust being monitored by Prospero,  J.M. 2006 for more than 40years in Barbados. Because of these investigations, scientists have started to connect several diseases of marine organisms to microbial pathogens that have been identified in dust storms (Griffin, et al., 2004). According to this review, the microbiological research conducted till date has identified wide range of airborne pathogenic microorganisms that move great distances through the atmosphere and these more risk-oriented studies need to be conducted.

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